擦老藥-落建minoxidil
•1988年，落建成為有史以來創新取得美國FDA核准的外用生髮產品，19年來落建已成為全世界最受歡迎與信賴的外用生髮產品之一。
包括美國、英國、香港與台灣等國家，均通過政府衛生單位嚴格審核而上市。實驗證明，5人使用，4人有效。落建的Minoxidil成分可以刺激毛囊，幫助改善落髮狀況並促進毛髮生長，使頭髮更長，更茂密。 Minoxidil 此類藥物主要的作用並不是用來刺激毛髮生長,而是用來降血壓的,它的副作用是多毛症,所以意外的被降低劑量拿來當作治療雄性禿的有效藥物。 •經口服投與的 minoxidil主要是對周邊血管有直接的擴張作用，因此可以藉著減少週邊血管的阻力來降低升高的收縮壓和舒張壓。可是用於治療雄激素性禿髮的外用製劑真正的藥理機轉尚不明確，純粹是因為臨床醫師在治療高血壓患者身上觀察到有毛髮增生的副作用。
落建minoxidilz有效豐富的相關專利
(1) •United States Patent Application20090069359 Kind Code A1 Cappello; John V. March 12, 2009 Topical and transdermal treatments using urea formulation •局部和經皮下吸收治療使用尿素劑型 •Abstract •Various medical conditions, some previously treated by injection or surgery, are effectively treated by a topical application of a composition of urea and a chemotherapeutic agent. Such agents include sclerosing agents, vasodilators, botulinum toxin and minoxidil. Conditions as diverse as spider veins, erectile dysfunction, facial wrinkles, hair loss and baldness can be effectively treated with the compositions. •有很多不同的藥物環境,有些要用注射或手術來做事先地治療,尿素的合成物和化學療法的製劑用來局部的治療是很有效的.這些製劑包含硬化劑,血管擴張劑,肉毒桿菌毒素,和minoxidil..像是蜘蛛脈,勃起功能障礙,臉部皺紋,掉髮和禿頭這樣的多變的藥物環境用這些合成的製劑是可以有有效的治療效果. •
(2) •United States Patent Application20030108500 Kind Code A1 Imamura, Koji ; et al. June 12, 2003 Hair growth stimulant compositions •刺激毛髮生長的合成藥物 •Abstract •Preparations containing minoxidil at a high concentration which scarcely show the precipitation of crystals even at low temperatures and have a high stability. In preparations containing 10 to 50% by mass of water and 3% by mass or more of minoxidil, hair growth stimulant compositions further containing 8 to 30% of one or more polyhydric alcohols and having a pH value of 5.5 to 6.5 scarcely show precipitation of crystals and have a high stability. •製備含有高濃度的minoxidil幾乎沒有出現結晶狀的沉澱物,甚至是在低溫度下還有很高的安定性.製備含有10到50%質量的水和3%質量或是多一點的minoxidil,刺激毛髮生長的合成物更包含了8到30%的minoxidil或多一點的多元醇,並且在PH值5.5~6.5的條件下幾乎沒有出現結晶狀的沉澱物還有很高的安定性. •
(3) •United States Patent Application20030170191 Kind Code A1 Imamura, Koji ; et al. September 11, 2003 Hair growth stimulant compositions with sustained action •有持久作用的刺激毛髮生長的合成藥物 •Abstract •Minoxidil preparations having a sustained action by which a fully satisfactory effect of stimulating hair growth can be obtained when applied once a day. Namely, hair growth stimulant compositions with a sustained action, which comprise (A) 2 to 6% by mass of minoxidil and (B) 5 to 30% by mass of a mixture of 1,3-butylene glycol or dipropylene glycol with glycerol blended at a weight ratio of 10:1 to 1:4, exert an excellent effect of stimulating hair growth. •Minoxidil的製備劑有持久的作用,在刺激毛髮生長方面,只要一天使用一次,就能有令人滿意的效果.也就是說,有著持久作用的刺激毛髮生長的合成藥物,包含(A)2~6%質量的minoxidil (B)5~30%質量的1,3丁烯乙二醇或二丙二醇混甘油以重量10:1到1:4來混合來發揮刺激毛髮生長最大的效用 •
(4) •United States Patent Application20040204433 Kind Code A1 Imamura, Koji ; et al. October 14, 2004 Hair growth stimulant compositions •刺激毛髮生長的合成藥物 •Abstract •Preparations containing minoxidil at a high concentration which scarcely show the precipitation of crystals even at low temperatures and have a high stability. In preparations containing 10 to 50% by mass of water and 3% by mass or more of minoxidil, hair growth stimulant compositions further containing 8 to 30% of one or more polyhydric alcohols and having a pH value of 5.5 to 6.5 scarcely show precipitation of crystals and have a high stability. •製備含有高濃度的minoxidil幾乎沒有出現結晶狀的沉澱物,甚至是在低溫度下還有很高的安定性.製備含有10到50%質量的水和3%質量或是多一點的minoxidil,刺激毛髮生長的合成物更包含了8到30%的minoxidil或多一點的多元醇,並且在PH值5.5~6.5的條件下幾乎沒有出現結晶狀的沉澱物還有很高的安定性.
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